Gross morphology of wild-type and p75NTR mutant mice
| Genotype | p75NTR +/+ | p75NTR+/− | p75NTR −/− |
|---|---|---|---|
| Body weight (gm) | 27.1 ± 1.2 (n = 6) | 25.6 ± 2.1 (n = 6) | 26.4 ± 1.1 (n = 5) |
| Brain weight (mg) | 458.3 ± 4.3 (n = 6) | 461.5 ± 6.9 (n = 6) | 448.0 ± 1.6 (n = 5) |
| Number of sections with medial septum | 36.0 ± 0.9 (n = 9) | 38.8 ± 0.7 (n = 5) | 35.7 ± 0.7 (n = 9) |
| Rostrocaudal length of MS (μm) | 1080 ± 28 (n = 9) | 1164 ± 22 (n = 5) | 1070 ± 22 (n = 9) |
| Volume of MS (mm3) | 0.20 ± 0.03 (n = 5) | 0.17 ± 0.01 (n = 5) | 0.21 ± 0.01 (n = 5) |
Mean ± SEM. The rostrocaudal length of medial septum was calculated by multiplying the total number of consecutive sections (30 μm each) containing medial septum by 30 μm. The volume of medial septum was measured by unbiased stereology with optical disector;n = number of animals.