Estimated levels of COI mRNA expression detected byin situ hybridization in basal ganglia and mesencephalon of monkeys and humans
| GPe | GPi | STN | SNpr | |
|---|---|---|---|---|
| Monkeys | ||||
| Controls | 0.77 ± 0.10 | 0.81 ± 0.10 | 0.61 ± 0.12 | 0.71 ± 0.05 |
| MPTP | 1.28 ± 0.15 | 1.55 ± 0.16a | 1.22 ± 0.03c | 1.45 ± 0.15c |
| MPTP + l-DOPA | 0.94 ± 0.19 | 0.96 ± 0.12b | 0.89 ± 0.20 | 0.96 ± 0.10d |
| Humans | ||||
| Controls | 1.50 ± 0.18 | 1.59 ± 0.24 | 1.07 ± 0.10 | 1.32 ± 0.09 |
| PD patients | 1.40 ± 0.32 | 1.60 ± 0.37 | 1.87 ± 0.04 | 1.50 ± 0.20 |
Estimation of COI mRNA levels detected by in situhybridization in basal ganglia and mesencephalic structures in monkeys (control, MPTP-intoxicated, and MPTP-intoxicated receivingl-DOPA treatment) and humans (control subjects and PD patients). COI mRNA levels were estimated by hybridization of [35S]-labeled cRNA and expressed as silver grain density (grains/μm2) over labeled cells. Values represent the mean ± SEM. Fifty neurons were evaluated in each structure in each subject. ap < 0.05 compared with controls; bp < 0.05 compared with MPTP-intoxicated monkeys;cp < 0.01 compared with controls;dp = 0.05 compared with MPTP-intoxicated monkeys. GPe, External segment of the globus pallidus; GPi, internal segment of the globus pallidus; SNpr, substantia nigra pars reticulata; STN, subthalamic nucleus.