Genotype | Genetic background | Percent seizing | Latency (min) | Total convulsion time (sec) | Mortality (%) |
---|---|---|---|---|---|
+/+ | hybrid | 74 | 29.3 ± 3.0 | 121 ± 18 | 18 |
−/− | hybrid | 86 | 21.5 ± 4.1 | 221 ± 251-160 | 43* |
TG | hybrid | 71 | 31.5 ± 3.5 | 115 ± 20 | 11 |
+/+ | 129 Sv | 76 | 30.6 ± 4.0 | 107 ± 25 | 0 |
−/− | 129 Sv | 88 | 20.9 ± 3.0 | 184 ± 30 | 13 |
Hybrid mice were given 25 mg of kainate/kg body weight and congenic mice (129 Sv) were given 35 mg of kainate/kg body weight. Latencies and convulsion times are the means ± SEM, n ≥ 24 for each group.
↵* Significantly greater than +/+ hybrid mice;p < 0.05, χ2 analysis.
↵F1-160 Significantly greater than +/+ hybrid mice; p < 0.01, unpaired t test.