Absolute dopamine levels are unaltered in rat brain by PCP or HA966
| PFC | Saline | PCP (10 mg/kg) |
| Saline | 1.47 ± 0.25 | 1.21 ± 0.18 |
| R-(+)HA966 (15 mg/kg) | 1.18 ± 0.22 | 1.40 ± 0.16 |
| S-(−)HA966 (3 mg/kg) | 1.06 ± 0.23 | 1.12 ± 0.16 |
| NAc | ||
| Saline | 89.98 ± 22.66 | 37.42 ± 7.00 |
| R-(+)HA966 (15 mg/kg) | 55.24 ± 22.51 | 46.44 ± 19.55 |
| S-(−)HA966 (3 mg/kg) | 83.28 ± 5.72 | 46.56 ± 13.38 |
| STR | ||
| Saline | 191.67 ± 13.12 | 211.04 ± 18.58 |
| R-(+)HA966 (15 mg/kg) | 185.62 ± 23.64 | 220.48 ± 14.48 |
| S-(−)HA966 (3 mg/kg) | 234.96 ± 7.96 | 218.12 ± 5.52 |
Neither phencyclidine nor HA966 significantly alters DA concentrations in rat brain, indicating that all drug effects on DA turnover are dependent on changes in DOPAC concentrations. Results are expressed as mean DA concentration in ng/mg protein ± SEM.