Table 5.

D2 DA receptor densities (fmol/mg protein) in the posterior striatum after injection into the midbrain of pTHpkcΔ, pTHpkcΔGG, or PBS

ConditionHemisphereVentromedialPosterior striatal regionDorsolateral
VentrolateralDorsomedial
pTHpkcΔInjected321  ± 25*598  ± 73*299  ± 42422  ± 61
n = 4Noninjected284  ± 30549  ± 73280  ± 42410  ± 57
pTHpkcΔGGInjected245  ± 25499  ± 73211  ± 42324  ± 61
n = 4Noninjected242  ± 30521  ± 73222  ± 42344  ± 57
PBSInjected246  ± 28550  ± 84287  ± 48424  ± 70
n = 4Noninjected226  ± 34563  ± 84304  ± 48433  ± 66
  • Two weeks after gene transfer, D2 DA receptor levels were determined in each of four quadrants in the anterior, medial, and posterior striatum. The D2 DA receptor levels (mean ± SEM) in the posterior striatum are shown here. D2 DA receptor density in the injected hemisphere was significantly greater than in the control hemisphere of rats in the pTHpkcΔ group (p < 0.05), but not in the control groups, as determined by ANOVA.

  • p < 0.025, Newman–Keuls test.