Condition | Hemisphere | Ventromedial | Posterior striatal region | Dorsolateral | |
---|---|---|---|---|---|
Ventrolateral | Dorsomedial | ||||
pTHpkcΔ | Injected | 321 ± 25* | 598 ± 73* | 299 ± 42 | 422 ± 61 |
n = 4 | Noninjected | 284 ± 30 | 549 ± 73 | 280 ± 42 | 410 ± 57 |
pTHpkcΔGG | Injected | 245 ± 25 | 499 ± 73 | 211 ± 42 | 324 ± 61 |
n = 4 | Noninjected | 242 ± 30 | 521 ± 73 | 222 ± 42 | 344 ± 57 |
PBS | Injected | 246 ± 28 | 550 ± 84 | 287 ± 48 | 424 ± 70 |
n = 4 | Noninjected | 226 ± 34 | 563 ± 84 | 304 ± 48 | 433 ± 66 |
Two weeks after gene transfer, D2 DA receptor levels were determined in each of four quadrants in the anterior, medial, and posterior striatum. The D2 DA receptor levels (mean ± SEM) in the posterior striatum are shown here. D2 DA receptor density in the injected hemisphere was significantly greater than in the control hemisphere of rats in the pTHpkcΔ group (p < 0.05), but not in the control groups, as determined by ANOVA.
* p < 0.025, Newman–Keuls test.