ChAT levels in sham versus192IgG-saporin-lesioned rats
| Brain region | ChAT Level (mean ± SEM) | |||
|---|---|---|---|---|
| Experiment 1 | Experiment 2 | |||
| Sham (n = 10) | Lesion (n = 9) | Sham (n = 11) | Lesion (n = 10) | |
| Hippocampus | 37.8 ± 2.0 | 12.8 ± 3.6*** | 48.3 ± 4.1 | 15.2 ± 4.5*** |
| Anterior cortex | 35.2 ± 1.4 | 15.3 ± 3.1*** | 39.9 ± 2.7 | 19.1 ± 3.8** |
| Posterior cortex | 35.3 ± 1.3 | 20.1 ± 4.6* | 39.6 ± 4.0 | 23.6 ± 3.0* |
| Olfactory bulbs | 56.0 ± 9.8 | 20.9 ± 3.5* | ||
| Caudate | 76.2 ± 7.6 | 68.0 ± 10.1 | ||
ChAT activity is presented as nanomoles of ACh formed per hour per milligram of protein. Significant reductions were detected in hippocampus, anterior cortex, posterior cortex, and olfactory bulbs.
*–***Significantly different compared with sham controls. *p < 0.01; **p < 0.001; ***p < 0.0001.