Regional cortical 5-HT and NET densities in control and methamphetamine-treated baboons
| Frontal cortex | Parietal cortex | Temporal cortex | ||||
|---|---|---|---|---|---|---|
| 5-HT transporter | NE transporter | 5-HT transporter | NE transporter | 5-HT transporter | NE transporter | |
| Control (n = 3) | 772.2 ± 74.4 | 362.7 ± 79.2 | 396.1 ± 68.3 | 446.9 ± 57.7 | 921.0 ± 75.8 | 263.6 ± 24.7 |
| Methamphetamine (n = 3) | 537.7 ± 81.55-a | 345.9 ± 54.3 | 268.5 ± 55.3 | 464.5 ± 37.0 | 575.6 ± 84.55-a | 268.6 ± 30.3 |
5-HTT and NET densities were measured with [3H]paroxetine and [3H]nisoxetine, respectively. Methamphetamine was given intramuscularly at a dose of 2 mg/kg. Each dose was given four times, at 2 hr intervals. Animals were killed for neurochemical studies 2–3 weeks after methamphetamine treatment. Control values represent the mean ± SEM (n = 3). Values are in μg/mg tissue.
↵F5-a Designates significant difference from control (p < 0.05).