Table 1.

Levels of 3α,5α-THP

CNS(ng/gm)Serum (ng/ml)
Pseudopregnancy, day 1040  ± 6.2*
Pseudopregnancy, day 1213.20  ± 0.48*28  ± 3.5*
Pseudopregnancy + MK-9064.84  ± 0.599  ± 2
Pseudopregnancy and ovx, day 113.37  ± 0.703.8  ± 0.5
Control1.75  ± 0.0611  ± 2.8

  • CNS and serum blood levels of 3α,5α-THP are elevated during pseudopregnancy as demonstrated by RIA results. Ovariectomy or injection of a 5α-reductase blocker (MK-906) on day 11 of pseudopregnancy significantly lowered levels of 3α,5α-THP, assessed on day 12, below those measured on days 10 and 12 of pseudopregnancy, ovx, Ovariectomized. (n = 4–6 animals per group, assessed in triplicate).

  • *p < 0.05 versus MK-906, ovx, and control.