Table 1.

Parameters of the voltage dependence of activation and inactivation and recovery from inactivation

Recovery from Inactivation
ActivationInactivationτ1τ2τ3n
ChannelV½(mV)z (eo)nV½ (mV)a (mV)nmsec%msec%msec%
Scn8a−8.8  ± 43.9  ± 0.35−55  ± 36.8  ± 0.955.5  ± 0.755  ± 5550  ± 16045  ± 5ND1-aND1-a6
Scn8a + β1 + β2−17  ± 44.2  ± 0.86−51  ± 14.9  ± 0.263.8  ± 1.0100ND1-bND1-bND1-bND1-b5
Rat1−17  ± 44.8  ± 0.58−35  ± 25.2  ± 0.561.9  ± 0.634  ± 446  ± 2730  ± 12280  ± 13036  ± 134
Rat1 + β1 + β2−15  ± 23.9  ± 0.46−41  ± 24.8  ± 0.631.4  ± 0.682  ± 113  ± 48.6  ± 4.0ND1-cND1-c4
Rat2−18  ± 55.0  ± 1.210−42  ± 47.4  ± 1.033.3  ± 0.639  ± 9130  ± 2044  ± 9890  ± 36017  ± 55
Rat2 + β1 + β2−22  ± 44.5  ± 0.45−57  ± 44.5  ± 0.352.2  ± 0.293  ± 147  ± 443.5  ± 2.3ND1-dND1-d5
  • F1-a ND, not determined because recovery for these channels was best fit with a double-exponential equation.

  • F1-b ND, not determined because recovery for these channels was best fit with a single-exponential equation.

  • F1-c ND, not determined because the time constant was >1.5 sec and could not be accurately quantified.

  • F1-d ND, not determined because the percentage of current recovering with τ3 was <4%.