Fibers n (A, C) | Tests n (A, C) | Impulses/30 sec evoked by consecutive trains of von Frey hair stimuli | |||||
---|---|---|---|---|---|---|---|
(1) Stimulus train median; range | Treatment | (2) Stimulus train median; range | Treatment | (3) Stimulus train median; range | |||
I | 29 (19, 10) | 42 (28, 14) | 23.0; 2–244 | 21.0; 1–295* | |||
II | 8 (5, 3) | 13 (8, 5) | 40.0; 6–98 | Contr. sol. | 35.0; 2–113* | ||
III | 40 (24, 16) | 40 (24, 16) | 9.0; 2–244 | IS | 21.0; 2–337** | ||
IV | 5 (2, 3) | 10 (4, 6) | 29.0; 0–68 | Contr. sol. | 21.5; 0–64* | IS | 48.0; 4–98** |
Consecutive trains of von Frey stimuli were applied within 10 min. Treatment between two trains: I, none; II, 2 min application of control solution (Contr. sol.); III, 2 min application of inflammatory soup (IS); IV, application of control solution between (1) and (2) stimulus train followed by IS application between (2) and (3) stimulus train. Some A and C fibers were tested twice with two consecutive trains using two different von Frey hairs. 11/19 A and 6/10 C fibers listed under I were additionally exposed to IS. These fibers and the corresponding responses are therefore also included in III. The remaining eight A and four C fibers of I were either exclusively mechanically stimulated without any treatment between two stimulus trains (3 A, 1 C) or additionally received control solution between two trains (5 A, 3 C). The responses of the latter fibers induced before and after application of control solution are given under II. A subgroup (2/5 A, 3/3 C) of the latter were tested further by IS; results are given under IV. Wilcoxon matched-pairs test; *p > 0.15; **p < 0.005.