Volumes of striatal excitotoxic lesions (average ± SEM) in rats in association with cerebellar lesion and FN stimulation
| Group (n) | Lesion volume (mm3) | Percent of sham striatal lesion |
|---|---|---|
| Intact cerebellum + stimulation | ||
| Sham stimulation (4) | 41.3 ± 1.3 | 100.0 |
| FN stimulation (5) | 15.5 ± 4.5 | 37.5* |
| DN stimulation (4) | 40.4 ± 4.9 | 97.8 |
| Cerebellar lesions + FN stimulation | ||
| FN-lesion (6) | 29.1 ± 7.5 | 70.5 |
| DN-lesion (4) | 13.0 ± 3.7 | 31.5* |
| FN-sham-lesion (5) | 23.2 ± 6.1 | 56.2* |
The FN was stimulated 5 d after bilateral FN lesion, DN lesion, or after injection of vehicle alone into the FN (FN-sham-lesion). Three days later, IBO was microinjected into the striatum, and 24 hr later, volumes were compared with matched nonlesioned (Intact) FN-stimulated rats and control DN- or sham-FN-stimulated rats. Lesion of the intrinsic FN neurons abolishes the neuroprotective effects of FN stimulation.
*p < 0.05 compared with matching control; ANOVA and SNK test.