Volumes of MCA infarction (average ± SEM), corrected for edema, in rats in association with cerebellar lesion and FN stimulation
| Group (n) | Infarction volume (mm3) | Percent of sham MCA Occlusion |
|---|---|---|
| Intact cerebellum + stimulation | ||
| Sham stimulation (3) | 119.0 ± 6.0 | 100.0 |
| FN stimulation (3) | 75.2 ± 7.6 | 63.0* |
| DN stimulation (4) | 132.5 ± 9.7 | 90.1 |
| Cerebellar lesion + FN stimulation | ||
| FN-lesion (12) | 126.3 ± 8.3 | 105.8 |
| DN-lesion (4) | 87.3 ± 5.1 | 73.1* |
| FN-sham-lesion (6) | 95.9 ± 3.1 | 80.4 |
The FN was stimulated 5 d after bilateral FN lesion, after DN lesion, or after injecting vehicle alone in the FN (FN-sham-lesion). Immediately after FN stimulation, the MCA was occluded, and 24 hr later, volumes were compared with matched nonlesioned (Intact) FN-stimulated rats and control DN- or FN-stimulated rats. Bilateral excitotoxic lesions of the intrinsic FN neurons abolish the reductions in infarction volume elicited by FN stimulation.
*p < 0.05 compared with matching control; ANOVA and SNK test.