Membrane characteristics of bladder afferent neurons exhibiting TTX-resistant action potentials in control and CYP-treated rats
| Control | CYP-treated | |
|---|---|---|
| No. of cells | n = 30 | n = 34 |
| Diameter (μm) | 23.6 ± 0.8 | 29.6 ± 1.0** |
| Input capacitance (pF) | 28.2 ± 1.8 | 41.8 ± 3.1** |
| RMP (mV) | −53.5 ± 2.0 | −51.5 ± 1.7 |
| Spike threshold (mV) | −21.4 ± 0.9 | −25.4 ± 0.5* |
| Spike duration (msec) | 7.9 ± 0.5 | 6.6 ± 0.5 |
| No. of action potentials (500 msec depolarization) | 1.2 ± 0.2 | 12.3 ± 1.4** |
| No. of cells | n = 25 | n = 22 |
| IA current density (pA/pF) (at 0 mV) | 109.4 ± 9.4 | 42.9 ± 6.6** |
| Decay time constant (τ) of IA current (msec) | 189.6 ± 8.8 | 201.2 ± 7.6 |
| IKV current density (pA/pF) (at 0 mV) | 52.8 ± 7.1 | 60.2 ± 6.1 |
Values are mean ± SEM. *p < 0.05 and **p < 0.01 indicate differences compared with control animals. RMP, Resting membrane potentials. Number of action potentials was obtained by injections of depolarizing current pulses (500 msec duration).