Table 2.

Serotonin axon density in various regions of the monkey brain 2 weeks and 7 years after MDMA treatment

Region	Control (10²)	MDMA–2 weeks (10²)	% Control	MDMA–7 years (10²)	% Control
Neocortex
CFA	647 ± 22	42 ± 10	7^a,c	410 ± 73	63^a,b
CCA	753 ± 31	96 ± 34	13^a,c	467 ± 52	62^a,b
CTp1	597 ± 46	31 ± 8	5^a,c	361 ± 44	60^a,b
CTp2	621 ± 70	36 ± 11	6^a,c	385 ± 46	62^a,b
CIs1	812 ± 34	118 ± 21	15^a,c	526 ± 40	65^a,b
CIs2	841 ± 22	125 ± 31	15^a,c	559 ± 11	66^a,b
CPf1	833 ± 30	144 ± 18	17^a,c	477 ± 63	57^a,b
CPf2	786 ± 72	116 ± 20	15^a,c	343 ± 46	44^a,b
CPa	640 ± 49	70 ± 20	11^a,c	415 ± 30	65^a,b
CSt	758 ± 60	64 ± 23	9^a,c	347 ± 14	46^a,b
Striatum
Cd1	149 ± 11	10 ± 0.6	7^2-a	50 ± 17	34^2-a
Cd2	210 ± 11	18 ± 0.1	9^2-a	51 ± 5	24^2-a
Cd3	167 ± 25	12 ± 0.2	8^2-a	50 ± 4	30^2-a
Put1	300 ± 41	53 ± 19	18^2-a	155 ± 56	52^2-a
Put2	251 ± 13	34 ± 4	14^2-a	108 ± 17	43^2-a
Put3	222 ± 25	34 ± 4	15^2-a	118 ± 1.8	53^2-a
Globus pallidus
GPex	527 ± 20	203 ± 21	39^a,c	1069 ± 37	203^a,b
GPin	766 ± 30	391 ± 64	51^a,c	902 ± 61	128^a,b
Limbic regions
DS	150 ± 14	85 ± 21	56^2-a	161 ± 2	107^2-b
LS	273 ± 33	198 ± 12	72	355 ± 37	130^2-b
TOf	454 ± 13	97 ± 10	21^a,c	486 ± 92	107^2-b
TOm	325 ± 33	102 ± 30	31^a,c	339 ± 48	104^2-b
ASt	384 ± 41	141 ± 39	37^a,c	398 ± 56	104^2-b
BAM	360 ± 36	135 ± 64	38^a,c	245 ± 17	68
BAL	605 ± 62	130 ± 23	22^a,c	510 ± 65	84^2-b
BLA	793 ± 56	228 ± 12	29^a,c	522 ± 13	66^a,b
BMA	705 ± 47	99 ± 8	14^2-a	262 ± 50	40^2-a
CeA	494 ± 61	171 ± 17	35^a,c	487 ± 46	98^2-b
LA	762 ± 80	34 ± 8	5^2-a	326 ± 29	43^2-a
Hypothalamus
ADH	1114 ± 16	510 ± 91	46^a,c	999 ± 123	90^2-b
DmH	1015 ± 25	619 ± 96	61^2-a	926 ± 122	91
VmH	934 ± 82	602 ± 75	64^2-a	957 ± 166	102
ALH	1127 ± 92	1111 ± 103	99	1201 ± 95	107
Thalamus
VA	302 ± 37	63 ± 11	21^a,c	459 ± 115	152^a,b
AV	454 ± 53	40 ± 2	9^2-a	250 ± 16	55^2-a
LD	515 ± 77	35 ± 5	7^2-a	249 ± 6	48
MD	727 ± 27	82 ± 3	11^a,c	673 ± 71	93^2-b
VLo	586 ± 14	37 ± 10	6^a,c	642 ± 137	110^2-b
VL	884 ± 22	64 ± 5	6^a,c	682 ± 117	77^2-b
VPI	290 ± 31	27 ± 1	9^a,c	366 ± 38	126^a,b
Hippocampus
FD	343 ± 28	195 ± 18	57^2-a	190 ± 47	55^2-a
CA1	273 ± 23	83 ± 7	30^2-a	157 ± 27	57^2-a
CA2	773 ± 36	365 ± 54	47^2-a	495 ± 61	64^2-a
CA3	225 ± 14	102 ± 10	46^2-a	149 ± 40	66
Sbc	342 ± 24	25 ± 5	8^2-a	67 ± 24	20^2-a
Other regions
ZI	427 ± 22	289 ± 12	68^2-a	475 ± 39	121
MM	1239 ± 72	232 ± 48	19^a,c	623 ± 49	50^a,b
IC	18 ± 3	5 ± 1	32^2-a	9 ± 0.1	51^2-a

MDMA was given subcutaneously at a dose of 5 mg/kg twice daily for 4 consecutive days. Values represent the mean ± SEM and are expressed in pixels.
↵F2-a Designates significantly different from control.
↵F2-b Designates significantly different from 2 week survival.
F2-c Designates significantly different from 7 year survival.