Effects of chronic treatment with antiproliferative agents on K+ current expression
| Treatment | RMP (mV) | Cm (pF) | V1/2(mV) (lower) | k | V1/2(mV) (upper) | k | Current density (pA/pF)a |
|---|---|---|---|---|---|---|---|
| Control1-b | −39.1 ± 2.3 | 5.0 ± 0.7 | −19.6 ± 0.91-e | 4.8 | 17.5 ± 4.41-e | 15.0 | 200 ± 24 |
| Forskolin1-c | −41.9 ± 2.6 | 9.1 ± 0.5* | −13.9 ± 5.5 | 7.3 | 20.6 ± 4.5 | 12.7 | 75 ± 15* |
| Dideoxyforskolin1-d | −35.0 ± 1.4 | 10.1 ± 1.6* | −14.7 ± 1.4 | 7.0 | 25.4 ± 7.0 | 16.0 | 120 ± 45* |
*p < 0.05.
A comparison of the electrophysiological properties of control OP cells and cells after chronic treatment with forskolin (50 μm) and dideoxyforskolin (50 μm) for 24–48 hr. After chronic treatment with these agents no changes were observed in the cell resting membrane parameters. Chronic treatment with forskolin and dideoxyforskolin did not significantly alter the voltage-dependent properties of both sustained outward current components. Forskolin and dideoxyforskolin did, however, reduce significantly the current density measured at +70 mV.
F1-a Current amplitudes measured at +70 mV.
↵F1-b n = 25.
↵F1-c n = 9.
↵F1-d n = 12.
↵F1-e n = 30.