Parameter | Values resulting in a free-running rhythm of 24.6 hr | Transition from steady state to limit cycle at values |
---|---|---|
rM, mRNA production rate constant | 1.0 hr−1 | 0.27 hr−1 |
rP, protein production rate constant | 1.0 hr−1 | 0.02 hr−1 |
qM, mRNA degradation rate constant | 0.21 hr−1 | 0.08 hr−1 |
qP, protein degradation rate constant | 0.21 hr−1 | 0.08 hr−1 |
n, Hill coefficient | 2.0 | 1.27 |
m, nonlinearity in protein synthesis cascade | 3.0 | 1.81 |
τ, duration of protein synthesis cascade | 4.0 hr | 2.21 hr |
k, scaling constant | 1 |