Summary of seizure trait parameters for B6, D2, F1, and F2 generation mice treated with PTZa
| Strain | n | Partial clonus latency | Generalized clonus latency | Tonic-clonic latency | Seizure score | ||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | Variance | Mean | Variance | Mean | Variance | Mean | Variance | ||
| B6 | 18 | 8.67* | 2.80 | 15.7** | 4.36 | 2.5*** | 0.85 | ||
| D2 | 20 | 3.95 | 1.66 | 4.42 | 2.49 | 16.7 | 7.56 | 12.3 | 3.0 |
| F1 | 15 | 5.73 | 4.71 | 6.74 | 4.78 | 34.9 | 134 | 8.44 | 17.2 |
| F2 | 511 | 5.73 | 8.98 | 7.26 | 15.3 | 23.5 | 192 | 9.64 | 60.5 |
F2-a Mice were given a single injection of PTZ (80 mg/kg, s.c.) and observed for 45 min to record latencies and determine seizure phenotype. Values for mean and variance are expressed in minutes.
*p < 0.005; **p < 0.001; ***p < 0.0005 versus respective D2 value (ANOVA, Neuman–Keuls).