Rise time (msec) | τ Inactivation (sec) | % of inhibition of current amplitude (1 mm Zn2+) | |||||
---|---|---|---|---|---|---|---|
0 mV | +20 mV | +40 mV | +20 mV | 0 mV | +20 mV | +40 mV | |
Kv2.1 | 22 ± 6 (10) | 13 ± 3 (10) | 11 ± 2 (10) | 3 ± 1 (11) | 21 ± 4 (7) | 16 ± 4 (8) | 13 ± 8 (9) |
Kv2.1+Kv2.3 | 51 ± 9 (14) | 21 ± 3 (10) | 19 ± 3 (22) | 12 ± 3 (26) | 40 ± 5 (9)* | 34 ± 4 (24)* | 29 ± 4 (28)* |
Kv2.1+Ch1 | 21 ± 6 (8) | 13 ± 5 (8) | 10 ± 3 (8) | 5 ± 1 (10) | 39 ± 7 (5)# | 24 ± 4 (4)§ | 20 ± 5 (4) |
Kv2.1+Ch2 | 86 ± 6 (8) | 43 ± 8 (8) | 24 ± 4 (8) | 13 ± 3 (11) | 66 ± 4 (4)& | 45 ± 1 (4)# | 33 ± 4 (4)# |
Kv2.1+Ch3 | 100 ± 13 (9) | 58 ± 12 (9) | 34 ± 9 (9) | 19 ± 1 (8) | 50 ± 8 (5)# | 43 ± 6 (5)# | 38 ± 6 (5)* |
Kv2.1+Ch4 | 21 ± 5 (13) | 12 ± 4 (13) | 10 ± 3 (13) | 4 ± 1 (7) | 56 ± 8 (5)# | 41 ± 9 (5)# | 30 ± 6 (5)# |
Kv2.1+Ch5 | 97 ± 8 (10) | 78 ± 15 (11) | 49 ± 14 (11) | 14 ± 3 (9) | 66 ± 9 (9)* | 55 ± 8 (9)* | 42 ± 6 (9)* |
Kv2.1+Ch6 | 22 ± 4 (19) | 12 ± 3 (15) | 10 ± 2 (15) | 2 ± 1 (10) | 42 ± 7 (5)# | 32 ± 6 (5)# | 26 ± 5 (5)& |
Kv2.1+Ch7 | 106 ± 9 (10) | 42 ± 15 (6) | 14 ± 3 (7) | 21 ± 10 (6) | 15 ± 5 (4) | 13 ± 3 (4) | 11 ± 5 (4) |
Kv2.1+Ch8 | 24 ± 4 (8) | 15 ± 3 (8) | 13 ± 2 (8) | 3 ± 1 (6) | 37 ± 3 (7)* | 27 ± 3 (7)* | 21 ± 4 (7) |
Values are given by mean ± SD, and the number of observations is given in parentheses. Inhibition by Zn2+ of each channel construct is compared with the potency of Zn2+to block Kv2.1 channels at the corresponding membrane potential. Statistical significance (Mann–Whitney U test) is indicated by the following symbols: *p<0.001;
p<0.005; &p<0.01; and §p<0.05.