Differential actions of sphingolipid products on ionic events, MAPK cascades, and cell survival in OLGS
| Cer | Sph | SPP | |
|---|---|---|---|
| IKirinhibition | ++ | − | − |
| Depolarization | ++ | − | ++ |
| Caiincreases | +/− | ++ | +/− |
| Hyperpolarization | − | ++ | − |
| MAPK activation | ↑p38α | ↑ERK2 | ↑ERK2 |
| Outcome | Apoptosis | Lysis/necrosis | Survival |
++, Consistent response; −, no effect; +/−, infrequent response; ↑, increased activity.