Table 2.

The effect of exogenous administration of plasminogen on neuronal sensitivity to excitotoxin in plg−/− mice

Genotype or treatment% length of hippocampal neuronal cell layer lost after kainate injection (1.5 nmol)
Plg+/−heterozygotes (n = 5)86.8  ± 6.4%
Plg−/− mice
 PBS intracerebral infusion (n = 3)7.1  ± 3.6%
 Plg intracerebral infusion (n = 4)81.9  ± 2.3%
 PBS IV injection (n = 3)5.2  ± 1.5%
 Plg IV injection (n = 4)7.4  ± 2.2%