Treatment (d) | PDE4A Frontal cortex | PDE4B Frontal cortex | PDE4B Nucleus accumbens |
---|---|---|---|
(mean ± SEM percent of vehicle) | |||
Control | 100 ± 8 | 100 ± 11 | 100 ± 10 |
Sertaline | |||
1 d | 95 ± 8 | 106 ± 17 | 103 ± 15 |
7 d | 119 ± 5 | 127 ± 12 | 120 ± 10 |
14 d | 121 ± 7* | 184 ± 15* | 152 ± 16* |
Rats were treated with vehicle or sertraline for 1, 7, or 14 d as described in Materials and Methods, and levels of PDE4A or PDE4B mRNA were measured by in situ hybridization analysis. Levels of mRNA were quantified in the regions indicated by densitometry. The results are expressed as mean ± SEM percent of control;n = 3 or 4 per group. *p < 0.05 compared with control (ANOVA and Fisher’s post hoctest).