Characteristics of nicotinic currents evoked in interneurons by application of agonists
| Parameter | Choline (mean ± SE) | ACh (mean ± SE) | Number of neurons |
|---|---|---|---|
| Pressure application | |||
| Peak amplitude (pA) | 95 ± 28 | 80 ± 11.1 | 6 |
| Rise time (msec) | 26 ± 2.5 | 43 ± 2.6 | 6 |
| U-tube application | |||
| Peak amplitude (pA) (type IA currents) | 124 ± 10.9 | 107 ± 9.3 | 46 |
| Peak amplitude (pA) (type IB currents) | 71 ± 11.2 | 113 ± 15.7 | 29 |
| Steady-state current (pA) (type IB currents) | 86 ± 11.4 | 29 | |
| Rise time (msec) (type IA currents) | 549 ± 30 | 596 ± 43 | 25 |
| Rise time (msec) (type IB currents) | 570 ± 34 | 679 ± 37 | 10 |
| Decay time constant (msec) (type IA currents) | 827 ± 61 | 1002 ± 78 | 25 |
| Decay time constant (msec) (type IB currents) | 1038 ± 235 | 4351 ± 756 | 9 |
Holding potential = −68 mV.