State amounts (minutes) | ||||||||
---|---|---|---|---|---|---|---|---|
5-HT1B+/+ | 5-HT1B−/− | |||||||
GR 127935 (mg/kg) | RU 24969 (mg/kg) | n | 0–2 hr | GR 127935 (mg/kg) | RU 24969 (mg/kg) | n | 0–2 hr | |
W | 0 | 0 | 8 | 42.3 ± 3.9 | 0 | 0 | 6 | 51.9 ± 3.2 |
— | 0.5 | 7 | 56.6 ± 1.6 | — | 3 | 6 | 52.8 ± 4.2 | |
1 | 0.5 | 8 | 39.2 ± 2.6 | 1 | 3 | 6 | 48.8 ± 7.8 | |
SWS | 0 | 0 | 8 | 71.2 ± 3.9 | 0 | 0 | 6 | 60.0 ± 3.6 |
— | 0.5 | 7 | 62.0 ± 2.0 | — | 3 | 6 | 66.3 ± 4.0 | |
1 | 0.5 | 8 | 74.0 ± 2.8 | 1 | 3 | 6 | 70.4 ± 7.4 | |
PS | 0 | 0 | 8 | 6.5 ± 0.2 | 0 | 0 | 6 | 8.9 ± 0.7 |
— | 0.5 | 7 | 1.4 ± 0.6* | — | 3 | 6 | 0.8 ± 0.4* | |
1 | 0.5 | 8 | 6.8 ± 0.7 | 1 | 3 | 6 | 0.8 ± 0.5* |
Results are expressed as minutes (mean ± SEM of 8 and 6 animals, respectively; n tests for each dose) during the 2 hr after injection in which the effects were observed.
*p < 0.05, significantly different from baseline (0); paired Student’s t test.