Basic properties of CF- and PF-EPSCs in the MK-801-treated mice
| EPSC | Group | 10–90% Rise time (msec) | Decay time constant (msec) | Amplitude (pA) 1-a | Paired-pulse ratio (%) 1-b |
|---|---|---|---|---|---|
| CF-EPSC | Control (sg) | 0.6 ± 0.1 (n = 50) | 9.3 ± 2.1 (n = 50) | 653 ± 211 (n = 29) | 81.0 ± 5.2 (n = 58) |
| MK-801 (sg) | 0.6 ± 0.1 (n = 53) | 9.4 ± 2.7 (n = 53) | 736 ± 209 (n = 43) | 81.8 ± 6.6 (n = 65) | |
| MK-801 (mlt-L) | 0.5 ± 0.1 (n = 17) | 8.9 ± 2.4 (n = 17) | 677 ± 238 (n = 14) | 81.2 ± 6.7 (n = 20) | |
| MK-801 (mlt-S) | 0.9 ± 0.6 (n = 15) | 10.4 ± 3.9 (n = 15) | 267 ± 134 (n = 13)* | 73.6 ± 11.3 (n = 17)1-160 | |
| PF-EPSC | Control (sg) | 1.6 ± 0.4 (n = 20) | 16.0 ± 4.0 (n = 20) | 175 ± 26 (n = 10) | |
| MK-801 (sg) | 1.5 ± 0.5 (n = 19) | 14.5 ± 4.5 (n = 19) | 177 ± 31 (n = 10) | ||
| MK-801 (mlt) | 1.5 ± 0.4 (n = 9) | 14.1 ± 3.7 (n = 9) | 183 ± 25 (n = 6) |
All data are expressed as mean ± SD and sample size. MK-801 or saline was intraperitoneally injected covering the critical period (P15–P16). The decay time constant was obtained by fitting the EPSC decay with a single exponential.
↵* p < 0.01,
↵F1-160 p < 0.001, compared with Control (sg) (t test).
↵F1-a Amplitude of CF-EPSCs was measured at the holding potential (Vh) of −20 mV.
↵F1-b Second EPSC/first EPSC: interpulse intervals were 100 msec for CF-EPSC and 50 msec for PF-EPSC.