Characteristics of GABAergic PSCs recorded from human cortical interneurons
| Parameter | Mean ± SE values (range) | |
|---|---|---|
| Control | ACh | |
| Frequency (Hz) | 0.46 ± 0.17 (0.11–0.95) | 3.05 ± 0.561-c (1.45–4.08) |
| Area of amplitude distribution for peak 1 (%)1-a | 81.6 ± 3.7 (71–89) | 39.8 ± 6.81-c (11–59) |
| Area of amplitude distribution for peak 2 (%)1-a | 18.4 ± 3.7 (15–38) | 60.2 ± 6.81-c (40–71) |
| Multi-peak events (%)1-b | 7.4 ± 1.1 (4.6–9.7) | 22.5 ± 2.11-c (17.8–27.8) |
Data were obtained from four neurons.
↵F1-a The distribution of PSC amplitudes was fit to a Gaussian function with two peaks. Because the events were sampled at 5 kHz, many multi-peak events (see below) appeared as single events in this analysis.
↵F1-b Multi-peak event was defined as a PSC with two or more peaks occurring within 20 msec of the onset of the starting event. These events were detected by sampling the data at 20 kHz.
↵F1-c p < 0.02 by paired studentt test, data compared to control group.