In situ hybridization of 5-HT1Areceptor mRNA in 5-HTT mutant mice
| 5-HT1A receptor mRNA (fmol/mg tissue) | ||||||
|---|---|---|---|---|---|---|
| Female | Male | |||||
| 5-HTT +/+ | 5-HTT +/− | 5-HTT −/− | 5-HTT +/+ | 5-HTT +/− | 5-HTT −/− | |
| Hypothalamus | ||||||
| AHN | 48 ± 4 | 39 ± 2 | 42 ± 4 | 36 ± 3 | 44 ± 7 | 44 ± 3 |
| LHN | 13 ± 2 | 10 ± 1 | 9 ± 1 | 6 ± 2 | 7 ± 2 | 5 ± 2 |
| VMN | 48 ± 6 | 54 ± 8 | 41 ± 9 | 23 ± 4 | 28 ± 3 | 34 ± 4 |
| DM | 31 ± 4 | 33 ± 2 | 29 ± 3 | 12 ± 2 | 16 ± 3 | 16 ± 3 |
| Midbrain | ||||||
| DR | 270 ± 25 | 231 ± 19 | 177 ± 9* | 371 ± 52 | 243 ± 26* | 221 ± 22* |
| MR | 252 ± 16 | 254 ± 15 | 257 ± 34 | 261 ± 32 | 278 ± 21 | 268 ± 31 |
The data are represented as mean ± SEM of five to seven mice.
↵* Significant difference from 5-HTT +/+ mice;p < 0.05.
The abbreviations are as same as listed in Figure 1.