Table 1.

Compared distributions of D3 receptor mRNA, binding, and immunoreactivity in rat brain structures

Brain regionD3R mRNA1-aD3R binding1-bD3R–IR1-c
Frontoparietal cortex++/++++
Frontal cortex+/−++
Nucleus accumbens shell++++++
Nucleus accumbens core+++
Islands of Calleja
 Granule cells+++++++
 Hilar region+/−++++++
Ventromedial striatum+++
Ventrolateral septum+/−++
Dorsal striatum0+/−+/−
Ventral pallidum+++++
Medial mammillary bodies+++++++++
Lateral mammillary bodies000
Lateral hypothalamus0++
Anteroventral thalamic nucleus+++++
Lateral habenula+/−++++
Hippocampus+/−+/−+/−
Ventral tegmental area+/−++
Substantia nigra pars reticulata+/−+/−+
Substantia nigra pars compacta+/−+++
Substantia nigra pars lateralis++/−+/−
A8 retrorubral field+++
Cerebellum (lobules 9 and 10)
 Purkinje cells++++/−+
 Molecular layer0+++++

  • ↵F1-a Data from Bouthenet et al. (1991) and Diaz et al. (1995).

  • ↵F1-b Data obtained with [3H]7-OH-DPAT from Diaz et al. (1995) or with [125I]trans-7-OH-PIPAT (present study).

  • ↵F1-c D3R immunoractivity.