Table 2.

Assessment of open field activity and Morris water maze performance

GroupOpen fieldMorris water maze
Crossing (1 min)Crossing (5 min)Retention (sec)Spatial probe (%)Speed (cm/sec)
PBS/CytC (n = 7)12.9  ± 1.323.6  ± 2.862.8  ± 16.46.5  ± 1.136.5  ± 1.3
PBS/NGF (n = 8)12.9  ± 2.528.8  ± 6.845.8  ± 12.86.1  ± 0.537.5  ± 1.1
Low-192IgG/CytC (n = 8)10.4  ± 1.426.4  ± 3.741.5  ± 12.07.4  ± 1.238.8  ± 0.5
Low-192IgG/NGF (n = 9)13.0  ± 1.734.6  ± 4.658.2  ± 14.86.3  ± 1.036.6  ± 1.0
High-192IgG/CytC (n = 6)12.3  ± 1.637.2  ± 3.074.3  ± 26.35.3  ± 1.142.0  ± 0.8*
High-192IgG/NGF (n = 6)9.8  ± 3.125.7  ± 9.875.0  ± 12.14.8  ± 1.139.2  ± 1.4
  • Open field task: grid crossing (1 min), reflecting initiation of spontaneous motor behavior; mean ± SEM of grid crossings in an 81 × 81 cm2 walled box. No significant differences among groups (F(5,38) = 0.50). Grid crossing (5 min), reflecting exploratory motor behavior; mean ± SEM of grid crossings. No significant differences among groups (F(5,38) = 0.91). Morris water maze: retention, reflecting recall of the platform position 10 d after the acquisition; mean ± SEM latencies of the retention block of two trials each of 90 sec maximum. No significant forgetting for any group over the retention period (F(5,38) = 0.56; p > 0.05). Spatial probe, reflecting acuity 1 d after retention, in finding the formerly present platform in the TA as defined by the intersection of PQ and PA; mean percentage of each groups total swimming distance ± SEM during a 90 sec spatial probe. No significant differences in spatial acuity among groups (F(5,38) = 0.76). Swim speed, reflecting general motor skills in the 90 sec spatial probe trial; mean ± SEM derived from the total distance swum in the fixed time interval. Significant difference in swim speed among groups (F(5,38) = 3.58; p < 0.01). *Significant difference from PBS/CytC, p < 0.05.