Group | Open field | Morris water maze | |||
---|---|---|---|---|---|
Crossing (1 min) | Crossing (5 min) | Retention (sec) | Spatial probe (%) | Speed (cm/sec) | |
PBS/CytC (n = 7) | 12.9 ± 1.3 | 23.6 ± 2.8 | 62.8 ± 16.4 | 6.5 ± 1.1 | 36.5 ± 1.3 |
PBS/NGF (n = 8) | 12.9 ± 2.5 | 28.8 ± 6.8 | 45.8 ± 12.8 | 6.1 ± 0.5 | 37.5 ± 1.1 |
Low-192IgG/CytC (n = 8) | 10.4 ± 1.4 | 26.4 ± 3.7 | 41.5 ± 12.0 | 7.4 ± 1.2 | 38.8 ± 0.5 |
Low-192IgG/NGF (n = 9) | 13.0 ± 1.7 | 34.6 ± 4.6 | 58.2 ± 14.8 | 6.3 ± 1.0 | 36.6 ± 1.0 |
High-192IgG/CytC (n = 6) | 12.3 ± 1.6 | 37.2 ± 3.0 | 74.3 ± 26.3 | 5.3 ± 1.1 | 42.0 ± 0.8* |
High-192IgG/NGF (n = 6) | 9.8 ± 3.1 | 25.7 ± 9.8 | 75.0 ± 12.1 | 4.8 ± 1.1 | 39.2 ± 1.4 |
Open field task: grid crossing (1 min), reflecting initiation of spontaneous motor behavior; mean ± SEM of grid crossings in an 81 × 81 cm2 walled box. No significant differences among groups (F(5,38) = 0.50). Grid crossing (5 min), reflecting exploratory motor behavior; mean ± SEM of grid crossings. No significant differences among groups (F(5,38) = 0.91). Morris water maze: retention, reflecting recall of the platform position 10 d after the acquisition; mean ± SEM latencies of the retention block of two trials each of 90 sec maximum. No significant forgetting for any group over the retention period (F(5,38) = 0.56; p > 0.05). Spatial probe, reflecting acuity 1 d after retention, in finding the formerly present platform in the TA as defined by the intersection of PQ and PA; mean percentage of each groups total swimming distance ± SEM during a 90 sec spatial probe. No significant differences in spatial acuity among groups (F(5,38) = 0.76). Swim speed, reflecting general motor skills in the 90 sec spatial probe trial; mean ± SEM derived from the total distance swum in the fixed time interval. Significant difference in swim speed among groups (F(5,38) = 3.58; p < 0.01). *Significant difference from PBS/CytC, p < 0.05.