Amount of free NGF and transgenic antibody in different tissues from transgenic control and anti-NGF transgenic mice
| Tissue | Mice | Free NGF | % Reduction3-a | αD11 recombinant antibody |
|---|---|---|---|---|
| Submaxillary gland | VH | 2.77 ± 0.17 μg/mg | ||
| Family 1 | 1.92 ± 1.92 μg/mg* | 30.6 | 82.9 ± 9.42 ng/mg | |
| Brain | VH | 31.3 ± 1.88 ng/mg | ||
| Family 1 | 16.6 ± 1.33 ng/mg* | 53 | 57.3 ± 10.37 ng/mg | |
| Dorsal muscles | VH | 11.6 ± 1.24 ng/mg | ||
| Family 1 | 4.5 ± 1.70 ng/mg* | 61.2 | 50.6 ± 1.24 ng/mg | |
| Abdominal muscles | VH | 10.3 ± 2.62 ng/mg | ||
| Family 1 | 11.3 ± 1.24 ng/mg | 10.3 | 12.6 ± 2.05 ng/mg | |
| Blood | VH | 46.3 ± 2.62 pg/ml | ||
| Family 1 | 22.3 ± 2.35 pg/ml* | 48.1 | 116 ± 18.45 ng/ml |
Values are the mean ± SEM (n = 3). *p < 0.001.
↵F3-a % reduction of free NGF in anti-NGF transgenic mice with respect to transgenic controls.