Table 1.

Arterial blood gases during experimental protocols

BaselineHypoxia30 min after hypoxia60 min after hypoxia
PaCO2 (mmHg)
 Control45  ± 246  ± 145  ± 245  ± 2
 Control + methysergide42  ± 11-16042  ± 141  ± 11-16042  ± 11-160
 Control + ketanserin44  ± 144  ± 144  ± 144  ± 1
 CIH39  ± 11-16038  ± 11-16040  ± 11-16040  ± 11-160
 CIH + methysergide40  ± 11-16041  ± 140  ± 11-16040  ± 11-160
 CIH + ketanserin43  ± 143  ± 144  ± 143  ± 1
PaO2 (mmHg)
 Control218  ± 1333  ± 1*210  ± 13208  ± 13
 Control + methysergide241  ± 8N/A228  ± 11224  ± 12
 Control + ketanserin218  ± 739  ± 1*227  ± 4222  ± 6
 CIH214  ± 1031  ± 1*218  ± 5215  ± 5
 CIH + methysergide200  ± 1133  ± 2*192  ± 9191  ± 10
 CIH + ketanserin251  ± 1838  ± 3*245  ± 12243  ± 19
  • Values are means ± 1 SEM. There were no significant differences in PaCO2 within groups.

  • * Indicates a significant decrease in PaO2 during hypoxic conditions relative to baseline (p < 0.05).

  • F1-160 Indicates a significant difference from corresponding PaCO2 value in control rats.