Table 1.

Number (n) of animals assessed by genotype and mean ± SEM values for parameters of body, brain, and barrel cortex development

5-HTTwthzkoOne-way ANOVAp value
n assessed at P71212 9
 Mean body weights (gm)4.58  ± 0.124.28  ± 0.393.84  ± 0.15F = 1.843 (df = 2, 29)0.178, n.s.
 Mean brain weights (gm)0.21  ± 0.020.22  ± 0.020.23  ± 0.02F = 0.142 (df = 2, 29)0.812, n.s.
n assessed at 4–5 months211519
 Mean body weights (gm)34.60  ± 1.2234.13  ± 1.4034.87  ± 1.47F = 0.121 (df = 2, 52)0.886, n.s.
 Mean brain weights (gm)0.35  ± 0.050.35  ± 0.010.33  ± 0.01F = 1.107 (df = 2, 52)0.338, n.s.
VMAT2wthzkoKruskal–Wallis test/one-way ANOVAp value
Total nassessed at P72843 6
 Mean body weights (gm)4.86  ± 0.244.84  ± 0.193.70  ± 0.67KW χ2 = 1.884 (df = 2)0.390, n.s.
n assessed at P7 in tangential sections2228 2
 Mean body weights (gm)4.26  ± 0.204.02  ± 0.201.63  ± 0.03*F = 6.706 (df = 2, 51)<0.01
 Mean brain weights (gm)0.14  ± 0.010.13  ± 0.010.08  ± 0.001*F = 3.362 (df = 2, 51)<0.05
 Mean barrel areas (μm2)29162  ± 209130705  ± 171317784  ± 374*F = 4.401 (df = 2, 17)<0.05
 Mean barrel area/brain weight (μm2/mg)9587.9  ± 4429169.0  ± 6029216.5  ± 258F = 0.181 (df = 2, 15)0.836, n.s.
 Mean barrel septa/area ratios 1.11 1.06 1.00F= 0.173 (df = 2, 16)0.843, n.s.
  • * Both ko versus wt and ko versus hz, p< 0.01 by a priori contrasts. n.s., Not significant.