Effect of receptor agonists on membrane potential of dopamine neurons
| Drug | Before | During drug | Change | p value | Number |
|---|---|---|---|---|---|
| Dopamine (4 or 10 μm) | −54.9 ± 1.0 | −60.1 ± 1.6 | −5.2* | <0.001 | 17 |
| DA + D2antagonist | −54.8 ± 2.3 | −53.9 ± 2.1 | 0.9 | 0.47 | 6 |
| Baclofen (10 μm) | −57.8 ± 3.2 | −76.9 ± 3.2 | −19.1* | <0.001 | 7 |
| Orphanin FQ (1 μm) | −56.1 ± 2.5 | −74.6 ± 1.9 | −18.6* | <0.001 | 9 |
Membrane potential (in mV) of dopamine neurons during and a comparable period just before the application of drugs is presented as mean ± SEM.
↵* denotes a statistically significant change in voltage analyzed with a paired Student's t test. The p value and number of cells used for each drug are shown in the last two columns.