ED50 value (95% confidence limits) | |||
---|---|---|---|
Wild-type | Heterozygote | Knock-out | |
Morphine | 3.8 (2.5, 5.2) | 2.9 (2.4, 3.7) | 1.5 (1.2, 1.8) |
M6G | 3.9 (2.8, 5.3) | 2.1 (1.4, 3.0) | 1.8 (1.3, 2.4) |
U50,488H | 3.2 (2.5, 4.0) | 1.5 (1.2, 1.8) | 0.25 (0.17, 0.36) |
NalBzoH | 33.3 (26.2, 42.1) | 20.2 (13.2, 30.7) | 8.5 (6.6, 10.9) |
ED50 values were determined from the cumulative dose–response curves shown in Figure 3. Values include the 95% confidence limits. Significance between values is defined as a lack of overlap of these 95% confidence limits.