Table 1.

Outward K+ currents in wild-type SCG neurons expressing Kv4.2W362F and/or Kv1.5W461F 1-a

Wild typeKv4.2W362F1-bKv1.5W461FKv1.5W461F + Kv4.2W362F
Type IType IIType IIIType IType IIType IIIType IType IIType IIIType IIType III
Peak current density (pA/pF)252  ± 20259  ± 22211  ± 18244  ± 35289  ± 31162  ± 21241  ± 22260  ± 33239  ± 28219  ± 42218  ± 35
IAf
 Density (pA/pF)81  ± 11111  ± 2164  ± 2067  ± 683  ± 9
 τ (msec)121  ± 1495  ± 8190  ± 18*97  ± 101-16072  ± 8
IAs
 Density (pA/pF)45  ± 367  ± 1540  ± 856  ± 14
 τ (msec)480  ± 21490  ± 31585  ± 47482  ± 61
IK
 Density (pA/pF)108  ± 1264  ± 9136  ± 11115  ± 7157  ± 25111  ± 2290  ± 1374  ± 10171  ± 36102  ± 44135  ± 60
 τ (msec)2560  ± 1872800  ± 1932200  ± 1762368  ± 1972473  ± 2542050  ± 2353127  ± 1973125  ± 4383089  ± 2342789  ± 3632473  ± 254
ISS
 Density (pA/pF)74  ± 545  ± 579  ± 668  ± 1572  ± 1565  ± 952  ± 848  ± 684  ± 765  ± 986  ± 12
n3094671815811310
  • F1-a All values are mean ± SEM; current densities and τdecay values were determined from currents recorded on depolarizations to +50 mV; n= number of cells.

  • F1-b Data from Malin and Nerbonne (2000).

  • * Values in Kv4.2W362F-expressing cells are significantly (p < 0.04) different from those recorded in wild-type cells.

  • F1-160 Values in Kv1.5W461F-expressing cells are significantly (p < 0.001) different from those recorded in Kv4.2W362F-expressing cells.