Engraftment efficiency of MT-c17.2 or GDNF-c17.2 cells in the adult striatum of wild-type and nude CD-1 mice
| 14 d WT | 30 d WT | 120 d WT | 120 d Nude | |
|---|---|---|---|---|
| MT-c17.2 grafts (β-Gal-positive) | 3 /3 (100%) | 3 /8 (37.5%) | 0 /8 (0%) | 3 /3 (100%) |
| GDNF-c17.2 grafts (GDNF-positive) | 4 /4 (100%) | 5 /12 (41.6%) | 1 /8 (12.5%) | 3 /3 (100%) |
Animals showing β-Gal- or GDNF-immunoreactive cells in the striatum at the indicated time points were considered as positive. In general, most of the animals showed either a large engraftment (see Figs. 3, 4) or absence of positive cells. The engraftment efficiency of MT-c17.2 or GDNF-c17.2 cells was 100% in nude CD-1 mice (Nude) but declined over time in wild-type mice (WT).