Table 1.

Deactivation time constants

Drug	Wash	τ (msec)	n	Drug	Wash	τ (msec)	n
1 μmAlph	Control	310.2 ± 48.7	4	1 mmGABA	Control	376.3 ± 56.9	5
1 μm Alph	100 μmBic	132.7 ± 32.4	4	1 mm GABA	100 μm PTX	61.0 ± 15.6	5
10 μmAlph	Control	665.0 ± 47.2	3	3 μmGABA	Control	283.4 ± 22.0	5
10 μmAlph	100 μm Bic	60.8 ± 5.7	3	3 μm GABA	1 μm DZP	362.9 ± 21.3	5
1 mm GABA	Control	328.3 ± 29.8	7	1 mm GABA	Control	318.7 ± 43.7	10
1 mm GABA	100 μmBic	320.1 ± 31.5	7	1 mm GABA	1 μm DZP	435.4 ± 75.4	10
3 μmGABA	Control	244.3 ± 32.3	6	1 mmGABA	Control	328.7 ± 47.6	4
3 μmGABA	100 μm Bic	218.4 ± 27.7	6	1 mm GABA	600 nm DMCM	276.5 ± 42.0	4
100 μmBic^1-a	n/a	8.7 ± 1.6^*	4	100 μmBic^1-b	n/a	6.3 ± 0.6^*	7

↵F1-a Effect on spontaneous activity in α1β3γ2L GABA_A receptors.
↵F1-b Effect on spontaneous activity of α1β3γ2L (L245S) GABA_A receptors. τ (msec) is the weighted time constant of deactivation, except for
↵* which indicates the time constant of inhibition onset.
Alph, Alphaxalone; Bic, bicuculline.