Group | 5.5 d | 4 hr | |||||
---|---|---|---|---|---|---|---|
1 | Twice daily HU210 | → | AM281 | ||||
2 | Twice daily vehicle | → | AM281 | ||||
3 | Twice daily vehicle | → | Lithium (8 meq/kg) | ||||
4 | Twice daily HU210 | → | Vehicle | ||||
5.5 d | 3 hr + 45 min | 15 min | |||||
5 | Twice daily HU210 | → | Vehicle | → | AM281 | ||
6 | Twice daily HU210 | → | Lithium (1 meq/kg) | → | AM281 | ||
7 | Twice daily HU210 | → | Lithium (2 meq/kg) | → | AM281 | ||
8 | Twice daily HU210 | → | Lithium (4 meq/kg) | → | AM281 | ||
9 | Twice daily HU210 | → | Lithium (8 meq/kg) | → | AM281 | ||
10 | Twice daily HU210 | → | Lithium (16 meq/kg) | → | AM281 | ||
11 | Twice daily vehicle | → | Lithium (4 meq/kg) | → | vehicle | ||
12 | Twice daily vehicle | → | Vehicle | → | vehicle | ||
5.5 d | 3 hr + 55 min | 5 min | |||||
13 | Twice daily HU210 | → | Lithium (4 meq/kg) | → | AM281 | ||
5.5 d | 3 hr + 30 min | 15 min | 15 min | ||||
14 | Twice daily HU210 | → | l-368,899 | → | Lithium | → | AM281 |
15 | Twice daily HU210 | → | Vehicle | → | Lithium | → | AM281 |
16 | Twice daily HU210 | → | l-368,899 | → | Vehicle | → | AM281 |
17 | Twice daily HU210 | → | Vehicle | → | Vehicle | → | AM281 |
18 | Twice daily vehicle | → | l-368,899 | → | Vehicle | → | Vehicle |
5.5 d | 3 hr + 45 min | 15 min | |||||
19 | Twice daily HU210 | → | Oxytocin | → | AM281 | ||
20 | Twice daily HU210 | → | Oxytocin fragment 4–9 | → | AM281 | ||
21 | Twice daily HU210 | → | Vehicle | → | AM281 | ||
10 d | 5.5 d | 3 hr + 45 min | 15 min | ||||
22 | Surgery | → | Twice daily HU210 | → | Oxytocin | → | AM281 |
23 | Surgery | → | Twice daily HU210 | → | Vehicle | → | AM281 |
See Materials and Methods for detailed description.