Counts of total and TH+ neuronal profiles in the petrosal ganglion from newborn wild-type (+/+/+/+),gdnf homozygous (+/+/−/−), bdnf homozygous (−/−/+/+), and bdnf/gdnf double homozygous (−/−/−/−) mice
| Genotype | Total profile | Change | TH+profile | Change |
|---|---|---|---|---|
| (bdnf/gdnf) | Number (n) | (%) | Number (n) | (%) |
| A. (+/+)/(+/+) | 3816 ± 369 (12) | 0 | E. 253 ± 12 (23) | 0 |
| B. (+/+)/(−/−) | 2329 ± 260 (10)1-a,1-d,1-e | −39 | F. 147 ± 12 (15)1-a,1-b,1-c | −42 |
| C. (−/−)/(+/+) | 1882 ± 150 (5)1-a,1-d | −51 | G. 106 ± 12 (13)1-a,1-d | −58 |
| D. (−/−)/(−/−) | 1435 ± 180 (5)1-a | −62 | H. 97 ± 14 (6)1-a | −62 |
Profile counts are shown as means ± SEM. Percent change is relative to wild-type.
↵F1-a Differs frombdnf+/+gdnf+/+ (wild-type).
↵F1-b Differs frombdnf−/−gdnf+/+ (BDNF knock-out;p < 0.05).
↵F1-c Differs frombdnf−/−gdnf−/− (BDNF/GDNF double knock-out;p < 0.05).
↵F1-d Not different frombdnf−/−gdnf−/− (BDNF/GDNF double knock-out).
↵F1-e Not different frombdnf−/−gdnf+/+ (BDNF knock-out).