Table 1.

Counts of total and TH+ neuronal profiles in the petrosal ganglion from newborn wild-type (+/+/+/+),gdnf homozygous (+/+/−/−), bdnf homozygous (−/−/+/+), and bdnf/gdnf double homozygous (−/−/−/−) mice

GenotypeTotal profileChangeTH+profileChange
(bdnf/gdnf)Number (n)(%)Number (n)(%)
A. (+/+)/(+/+)3816  ± 369  (12) 0E. 253  ± 12  (23)0
B. (+/+)/(−/−)2329  ± 260  (10)1-a,1-d,1-e −39F. 147  ± 12  (15)1-a,1-b,1-c −42
C. (−/−)/(+/+)1882  ± 150  (5)1-a,1-d −51G. 106  ± 12  (13)1-a,1-d −58
D. (−/−)/(−/−)1435  ± 180  (5)1-a −62H. 97  ± 14  (6)1-a −62
  • Profile counts are shown as means ± SEM. Percent change is relative to wild-type.

  • F1-a Differs frombdnf +/+ gdnf +/+ (wild-type).

  • F1-b Differs frombdnf −/− gdnf +/+ (BDNF knock-out;p < 0.05).

  • F1-c Differs frombdnf −/− gdnf −/− (BDNF/GDNF double knock-out;p < 0.05).

  • F1-d Not different frombdnf −/− gdnf −/− (BDNF/GDNF double knock-out).

  • F1-e Not different frombdnf −/− gdnf +/+ (BDNF knock-out).