Startle values for pulse alone and prepulse–pulse trials in isolation-reared and socially reared animals for PPI experiments shown in Figures 3-5
| Treatment | Socially reared animals | Isolation-reared animals | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Pulse alone | 4 dB | 8 dB | 12 dB | Pulse alone | 4 dB | 8 dB | 12 dB | ||
| Experiment 1 | None | 50.7 (1.8) | 32.3 (1.5) | 27.5 (1.3) | 22.6 (1.1) | 41.5 (1.5) | 30.6 (1.1) | 27.7 (1.1) | 24.5 (1.0) |
| Experiment 2 | Control | 49.0 (4.0) | 27.1 (2.46) | 24.0 (2.1) | 23.9 (2.8) | 50.1 (3.8) | 35.2 (3.6) | 30.3 (2.5) | 26.2 (30) |
| Haloperidol (0.1 mg/kg) | 53.4 (3.3) | 31.9 (2.2) | 24.1 (1.5) | 21.1 (1.5) | 57.5 (6.6) | 28.1 (2.4) | 22.65 (2.5) | 18.1 (1.3) | |
| NTR antagonist (100 μg/kg) | 59.3 (4.0) | 29.8 (2.5) | 20.7 (1.4) | 26.5 (3.3) | 35.61-160 (2.2) | 21.2 (1.3) | 21.4 (1.4) | 18.8 (1.5) | |
| Haloperidol + NTR antagonist | 45.8 (3.5) | 25.4 (2.3) | 19.1 (1.4) | 16.43 (1.9) | 43.5 (3.7) | 27.2 (1.5) | 25.9 (2.4) | 23.8 (2.8) | |
| Experiment 3 | Quetiapine (0 mg/kg) | 38.7 (3.5) | 23.1 (1.7) | 24.8 (2.1) | 16.8 (1.2) | 35.2 (4.3) | 26.5 (2.2) | 21.9 (2.6) | 21.6 (2.5) |
| Quetiapine (0.5 mg/kg) | 36.0 (3.6) | 19.2 (2.5) | 13.3 (1.4) | 13.9 (1.4) | 41.5 (3.4) | 25.9 (2.9) | 23.6 (2.5) | 21.1 (2.1) | |
| Quetiapine (2.0 mg/kg) | 36.3 (3.5) | 18.5 (1.2) | 15.7 (1.5) | 13.9 (1.3) | 30.2 (3.6) | 19.8 (2.1) | 15.8 (1.7) | 14.7 (1.7) | |
| Quetiapine (4.0 mg/kg) | 32.4 (3.4) | 16.3 (2.1) | 15.7 (2.1) | 11.0 (1.5) | 41.8 (3.5) | 19.7 (1.7) | 19.2 (2.3) | 17.8 (1.7) | |
| Quetiapine (5.0 mg/kg) | 45.3 (4.1) | 20.1 (2.3) | 13.9 (1.3) | 14.7 (1.8) | 40.6 (4.4) | 19.2 (2.1) | 13.3 (1.3) | 13.9 (1.6) | |
| Experiment 4 | Control | 81.1 (13.3) | 39.5 (3.9) | 34.7 (2.4) | 29.4 (2.5) | 50.3 (3.8) | 43.7 (4.0) | 33.2 (2.9) | 33.5 (3.8) |
| Quetiapine (2.0 mg/kg) | 35.5* (3.8) | 21.7 (2.2) | 18.7 (2.0) | 18.2 (1.8) | 51.6 (4.6) | 28.1 (3.0) | 22.4 (2.0) | 23.0 (2.1) | |
| NTR antagonist (100 μg/kg) | 52.0* (4.5) | 35.6 (3.4) | 28.3 (2.0) | 22.5 (2.5) | 52.4 (3.6) | 41.0 (4.2) | 37.1 (4.2) | 28.7 (2.8) | |
| Quetiapine + NTR antagonist | 54.6* (5.9) | 30.0 (3.7) | 24.3 (2.9) | 20.8 (2.6) | 55.2 (12.1) | 39.5 (5.9) | 26.8 (3.8) | 27.0 (4.8) | |
| Experiment 5 | Control | 56.0 (4.5) | 32.9 (2.3) | 30.6 (2.5) | 25.4 (2.1) | 51.9 (4.5) | 33.6 (2.9) | 31.0 (2.9) | 26.2 (2.5) |
| Quetiapine (5.0 mg/kg) | 45.3 (6.2) | 20.1 (2.2) | 14.5 (1.6) | 13.2 (1.4) | 40.6 (4.1) | 19.2 (2.1) | 13.4 (1.4) | 13.9 (1.6) | |
| NTR antagonist (100 μg/kg) | 76.6 (14.4) | 38.3 (4.8) | 34.1 (4.3) | 26.5 (3.3) | 47.4 (4.3) | 31.3 (3.4) | 25.5 (2.7) | 23.9 (2.8) | |
| Quetiapine + NTR antagonist | 56.7 (7.6) | 26.5 (2.7) | 21.5 (1.8) | 17.3 (1.8) | 32.6 (3.9) | 20.6 (2.5) | 17.9 (2.1) | 13.9 (1.5) | |
Data are arbitrary units expressed as mean ± SEM. All animals in the PPI studies were female.
↵* p < 0.05 compared with pulse alone amplitude in socially reared, vehicle-treated animals.
↵F1-160 p < 0.05 compared with pulse alone amplitude in isolation-reared, vehicle-treated animals. NTR, NT receptor.