Current density measurements in GluR2 mutant neurons
| C(pF) | Imax(pA) | Imax/C (pA/pF) | |
|---|---|---|---|
| GluR2(+/+), n = 8 | 45 ± 10 | 1878 ± 371 | 43 ± 4 |
| GluR2(+/−), n = 6 | 51 ± 8 | 2160 ± 287* | 45 ± 6 |
| GluR2(−/−),n = 6 | 34 ± 6 | 3027 ± 534* | 88 ± 5* |
Kainate current density was calculated by normalizing the peak current evoked by 3 mm kainate to cell capacitance calculated by integrating the capacitive transient evoked during each experiment by applying a voltage step of −10 mV from holding potential.
↵* One-way ANOVA with post hoc Bonferronit tests for statistical difference from GluR2(+/+) at p < 0.01.