Table 1.

Effects of developmental MDMA on adult brain monoamine concentrations in males expressed as nanomoles per gram tissue wet weight (mean ± SEM)

DoseP1–10P11–20
Hippocampus5-HT02.07  ± 0.052.21  ± 0.06
51.82  ± 0.041-160 2.03  ± 0.061-160
101.72  ± 0.051-160 1.94  ± 0.051-160
201.82  ± 0.081-160 2.08  ± 0.07*
NE02.76  ± 0.122.88  ± 0.11
52.88  ± 0.103.23  ± 0.111-160
103.00  ± 0.091-160 3.20  ± 0.121-160
202.94  ± 0.121-160 3.35  ± 0.081-160
Frontal cortex5-HT03.16  ± 0.103.15  ± 0.09
53.23  ± 0.103.00  ± 0.101-160
103.01  ± 0.102.80  ± 0.151-160
202.99  ± 0.092.93  ± 0.091-160
NE02.49  ± 0.082.44  ± 0.10
52.53  ± 0.062.59  ± 0.07
102.56  ± 0.092.43  ± 0.13
202.52  ± 0.072.64  ± 0.07
DA01.28  ± 0.231.70  ± 0.22
51.08  ± 0.101.24  ± 0.14
101.41  ± 0.111.32  ± 0.24
201.42  ± 0.141.56  ± 0.44
  • Rats were 105 d old at the time of assay. There were no significant effects of gender; therefore, only data for males are presented.

  • * p < 0.05,

  • F1-160 p < 0.01 compared with control within each region and neurotransmitter. Group sizes = 15 per cell. Group sizes were the same for females (n = 15 per cell). Dose is milligrams per kilogram per treatment with two treatments per day.