Control conditions | Experimental conditions | ||||
---|---|---|---|---|---|
Amounts (min) | Number | Amounts (min) | Number | ||
PS deprivation | |||||
5-HT1A+/+ (n = 6) | 0–6 hr | 12.5 ± 1.5 | 11.3 ± 1.0 | 20.8 ± 1.6* | 17.2 ± 1.6* |
6–12 hr | 18.3 ± 1.1 | 16.2 ± 1.5 | 20.1 ± 1.7 | 18.0 ± 2.6 | |
5-HT1A−/− (n = 6) | 0–6 hr | 20.2 ± 2.92-160 | 16.5 ± 1.82-160 | 23.1 ± 2.7 | 19.7 ± 2.2 |
6–12 hr | 25.8 ± 1.92-160 | 21.2 ± 2.2 | 28.3 ± 2.22-160 | 24.7 ± 1.8 | |
Immobilization stress | |||||
5-HT1A+/+ (n = 9) | 0–6 hr | 12.2 ± 1.1 | 10.3 ± 1.1 | 15.9 ± 2.2 | 15.0 ± 2.0* |
6–12 hr | 19.1 ± 1.1 | 16.1 ± 1.2 | 23.4 ± 1.5* | 22.1 ± 1.5* | |
5-HT1A−/− (n = 7) | 0–6 hr | 19.2 ± 2.12-160 | 16.6 ± 1.82-160 | 17.0 ± 1.8 | 15.1 ± 1.1 |
6–12 hr | 24.7 ± 3.0 | 21.4 ± 2.22-160 | 25.1 ± 1.5 | 23.1 ± 1.6 |
The data (mean ± SEM of n animals) represent the amounts of PS expressed as minutes and the number of PS episodes for the 0–6 and 6–12 hr periods of recovery after control (large platform) and PS deprivation (small platform) procedure (top) and control and immobilization stress (bottom).
↵* p < 0.05, significantly different from control conditions; paired Student's t test.
↵F2-160 p < 0.05, significantly different from 5-HT1A+/+ group; unpaired Student's ttest.