The frequency of GABAA sIPSCs is reduced after CCI and SNI
| Spontaneous IPSCs | Naive | CCI | SNI |
|---|---|---|---|
| Amplitude (pA) | |||
| All sIPSCs | 17.3 ± 2.4 (10) | 14.6 ± 2.2 (5) | 19.8 ± 3.0 (9) |
| GABAA | 12.1 ± 1.5 (7) | 13.0 ± 2.0 (6) | 16.3 ± 2.7 (8) |
| Glycine | 14.2 ± 2.9 (6) | 13.1 ± 1.1 (5) | 12.3 ± 2.3 (5) |
| Frequency (Hz) | |||
| All sIPSCs | 6.3 ± 1.2 (10) | 4.7 ± 1.3 (5) | 4.4 ± 1.0 (9) |
| GABAA | 5.8 ± 0.6 (7) | 3.9 ± 0.4 (7)3-150 | 1.8 ± 0.3 (8)3-150 |
| Glycine | 2.8 ± 1.2 (6) | 2.4 ± 0.6 (5) | 2.5 ± 1.1 (5) |
GABAA and glycine receptor-mediated sIPSCs were isolated pharmacologically with strychnine (0.5 μm) or bicuculline (5–10 μm), respectively. The frequency of GABAA sIPSCs decreased significantly after CCI (p = 0.02) and SNI (p < 0.0001). Numbers of neurons are indicated in parentheses.
↵F3-150 p < 0.05 compared with naive.