Table 2.

Effects of cocaine self-administration on rates of local cerebral glucose utilization in rhesus monkeys^2-a

	Food	Cocaine 0.03 mg/kg/inj	Cocaine 0.3 mg/kg/inj
Prefrontal cortex
Orbital (Areas 11, 12, 13)	44.3 ± 2	44.3 ± 3	47.4 ± 3
Medial (Areas 14, 24, 25, 32)	36.4 ± 2	29.3 ± 1^*	30.3 ± 1^*
Dorsolateral (Areas 45, 46)	44.6 ± 4	51.5 ± 4^*	55.8 ± 2^*
Anterior insular (Iai, Iam, Ial, G)	34.2 ± 3	25.2 ± 2^*	23.9 ± 3^*
Dorsomedial (Area 9)	42.5 ± 3	54.1 ± 3^*	59.0 ± 2^*
Other cortex
Area 6	48.7 ± 3	48.8 ± 5	45.8 ± 1
Area 4	49.1 ± 1	46.1 ± 5	50.1 ± 3
Area 5	50.4 ± 5	54.6 ± 5	57.2 ± 4
Area 7	46.8 ± 3	44.4 ± 4	47.0 ± 5
Temporal pole	40.3 ± 2	40.6 ± 2	39.0 ± 3
Entorhinal cortex	36.2 ± 4	34.8 ± 3	31.8 ± 2
Precommissural striatum
Rostral caudate	59.8 ± 4	46.5 ± 4^*	48.3 ± 2^*
Rostral putamen	60.0 ± 5	48.3 ± 5	50.0 ± 2
Caudal caudate	60.5 ± 3	51.0 ± 5	49.2 ± 2^*
Caudal putamen	61.8 ± 4	50.5 ± 5	47.7 ± 2
Rostral accumbens	48.0 ± 5	38.2 ± 3^*	37.7 ± 2^*
Nucleus accumbens-shell	44.5 ± 3	33.3 ± 4^*	32.5 ± 2^*
Nucleus accumbens-core	46.5 ± 3	40.2 ± 7	36.0 ± 2^*
Olfactory tubercle	47.0 ± 3	37.8 ± 3^*	35.0 ± 3^*
Basal ganglia
Ventral tegmental area	31.0 ± 1	27.8 ± 2	27.2 ± 1^*
Parabrachialis pigmentosus	31.3 ± 1	30.2 ± 2	30.0 ± 2
Substantia nigra pars compacta	46.8 ± 1	50.9 ± 4	45.4 ± 2
Substantia nigra pars reticulata	39.9 ± 1	37.4 ± 3	43.9 ± 2^*
Globus pallidus-external	29.8 ± 3	31.0 ± 3	36.5 ± 3^*
Globus pallidus-internal	30.8 ± 4	32.0 ± 4	40.5 ± 2^*
Ventral pallidum	36.2 ± 2	27.8 ± 3	30.3 ± 3
Subthalamic nucleus	56.5 ± 8	64.5 ± 9	68.3 ± 5^*
Red nucleus	42.5 ± 4	50.5 ± 4	56.3 ± 6^*
Thalamus
Ventral anterior	38.5 ± 5	39.3 ± 3	41.8 ± 1
Anterior ventral	49.0 ± 5	55.5 ± 2	62.2 ± 3^*
Paraventricular	34.6 ± 2	34.7 ± 2	36.8 ± 3
Mediodorsal-magnocellular	45.5 ± 4	55.3 ± 4^*	61.8 ± 4^*
Mediodorsal-parvicellular	49.2 ± 4	61.5 ± 4	70.5 ± 5^*
Centromedian	40.0 ± 5	46.0 ± 2	50.3 ± 7
Parafascicularis	42.5 ± 3	51.6 ± 3^*	53.3 ± 3^*
Ventralposterior	38.1 ± 5	44.2 ± 2	48.0 ± 5
Ventroposterolateral	33.1 ± 3	38.8 ± 4	40.8 ± 3
Limbic Regions
Lateral amygdala	36.1 ± 2	35.5 ± 2	39.5 ± 2
Basal-medial amygdala	41.4 ± 1	39.8 ± 4	44.0 ± 3
Basal-lateral amygdala	36.1 ± 1	33.4 ± 3	37.5 ± 3
Central amygdala	24.8 ± 1	22.8 ± 3	25.2 ± 1
Medial amygdala	27.5 ± 1	25.5 ± 3	28.8 ± 1
Medial septum	31.6 ± 3	31.0 ± 3	28.8 ± 2
Lateral septum	28.8 ± 3	27.7 ± 3	23.8 ± 2
Bed nucleus of stria terminalis	28.2 ± 2	22.6 ± 4^*	21.5 ± 1^*
Extended amygdala	32.4 ± 2	24.8 ± 3	26.6 ± 2
Hippocampus (CA1)	40.2 ± 2	41.5 ± 3	40.0 ± 3
Hippocampus (CA3)	34.3 ± 1	36.0 ± 2	34.5 ± 3
Hippocampus (Dentate gyrus)	35.8 ± 1	38.5 ± 3	35.3 ± 2
Subiculum	42.5 ± 2	43.5 ± 3	43.0 ± 2
Hypothalamus
Medial preoptic area	34.1 ± 3	28.4 ± 1	29.3 ± 4
Lateral preoptic area	30.0 ± 2	25.6 ± 1^*	27.6 ± 1
Lateral	28.3 ± 1	24.1 ± 2	30.1 ± 3
Dorsomedial	26.2 ± 2	24.6 ± 2	26.0 ± 2
Ventromedial	29.0 ± 1	24.3 ± 1	26.7 ± 2
Paraventricular	26.3 ± 2	23.8 ± 2	25.3 ± 2
Posterior	38.3 ± 6	28.8 ± 5	32.1 ± 6

↵F2-a Data represent rates of glucose utilization (μmol/100 gm/min) expressed as mean ± SEM.
↵* p <0.05 different from food control, one-way ANOVA followed by a post hoc least squares difference test comparing self-administration groups to food controls.