Table 1.

Acoustic startle reactivity in D1R wild-type (+/+), heterozygous (+/−), and knock-out (−/−) mice

D1R (+/+)D1R (+/−)D1R (−/−)
Apomorphine (ME)
 Vehicle84.4  ± 11.373.2  ± 8.097.4  ± 9.9
 5.0 mg/kg50.6  ± 5.8*41.9  ± 5.9*48.5  ± 11.9*
SKF82958
 Vehicle115.0  ± 21.3not tested84.0  ± 14.5
 0.30 mg/kg60.3  ± 6.4not tested106.9  ± 17.7
Amphetamine (ME)
 Vehicle128.0  ± 14.694.1  ± 16.5112.0  ± 10.2
 10.0 mg/kg80.7  ± 9.7*50.3  ± 14.8*59.3  ± 8.3*
Dizocilpine
 Vehicle69.7  ± 9.157.2  ± 6.076.7  ± 14.9
 0.3 mg/kg91.3  ± 7.681.8  ± 9.359.5  ± 8.0
  • Values (arbitrary units) represent mean startle magnitude ± SEM.

  • * p < 0.05 compared with vehicle control or main effect of drug treatment (ME).