Table 2.

Acoustic startle reactivity in D2R wild-type (+/+), heterozygous (+/−), and knock-out (−/−) mice

D2R (+/+)D2R (+/−)D2R (−/−)
Apomorphine (ME)
 Vehicle143.0  ± 19.8131.2  ± 15.0128.0  ± 15.2
 5.0 mg/kg81.6  ± 13.2*94.4  ± 10.2*96.4  ± 19.4*
SKF82958
 Vehicle99.4  ± 6.085.2  ± 8.879.2  ± 9.4
 0.30 mg/kg93.6  ± 11.487.6  ± 6.070.0  ± 7.2
Amphetamine
 Vehicle95.0  ± 22.278.8  ± 9.6103.4  ± 19.4
 10.0 mg/kg59.6  ± 9.894.6  ± 14.6121.4  ± 22.8
Dizocilpine
 Vehicle81.2  ± 10.2102.4  ± 10.8130.4  ± 20.0
 0.3 mg/kg105.8  ± 14.2115.6  ± 18.0126.8  ± 20.4
  • Values (arbitrary units) represent mean startle magnitude ± SEM.

  • * p < 0.05 compared with vehicle control or main effect of drug treatment (ME).