Changes in proN/OFQ and NOP gene expression in rat forebrain regions 6 hr after systemic administration of kainate (10 mg/kg)
| Control1-a | Kainate1-a | |||
|---|---|---|---|---|
| Right | Left | Right | Left | |
| proN/OFQ | ||||
| Amygdala | ||||
| Medial nucleus | 100 ± 17 | 98 ± 20 | 167 ± 22* | 157 ± 16* |
| Hippocampus | ||||
| Dentate gyrus | 43 ± 7 | 52 ± 7 | 69 ± 9 | 69 ± 9 |
| Thalamus | ||||
| Reticular nucleus | 58 ± 12 | 57 ± 13 | 158 ± 191-160 | 156 ± 221-160 |
| NOP | ||||
| Piriform cortex | 100 ± 5 | 101 ± 15 | 49 ± 41-160 | 56 ± 5* |
| Amygdala | ||||
| Medial nucleus | 87 ± 8 | 92 ± 7 | 45 ± 51-160 | 40 ± 31-160 |
| Thalamus | ||||
| Ventral nucleus | 46 ± 2 | 42 ± 4 | 30 ± 11-160 | 26 ± 3* |
| Hippocampus | ||||
| Dentate gyrus | 54 ± 4 | 53 ± 7 | 37 ± 3* | 36 ± 5* |
| CA3 | 90 ± 5 | 85 ± 15 | 45 ± 41-160 | 42 ± 4* |
| CA1 | 55 ± 7 | 48 ± 10 | 33 ± 4 | 32 ± 3 |
| Neocortex | ||||
| Layer IV | 54 ± 4 | 54 ± 5 | 32 ± 11-160 | 27 ± 31-160 |
↵* p < 0.05,
↵F1-160 p < 0.01 versus the corresponding region in controls; ANOVA and post hoc Newman–Keuls test.
↵F1-a Optical density values have been calculated as described in Materials and Methods and are expressed as percentage of the specific optical density over the right medial nucleus of the amygdala of controls (for proN/OFQ) or over the right piriform cortex of controls (for NOP). Data are the mean ± SE of four to six animals per group, each run in quadruplicate.