Association of MALS-1 with juvenile audiogenic seizure susceptibility in Black Swiss mice
| MALS-1 genotype | Age | Number of mice tested | Number of mice with seizure |
|---|---|---|---|
| Wild type (+/+) | 21 d | 25 | 17 (68%) |
| Heterozygote (+/−) | 21 d | 41 | 3 (7%) |
| Homozygote (−/−) | 21 d | 16 | 0 (0%) |
| Wild type (+/+) | 16 d | 11 | 8 (73%) |
| Heterozygote (+/−) | 16 d | 15 | 1 (7%) |
| Homozygote (−/−) | 16 d | 6 | 0 (0%) |
| Wild type (+/+) | 12 weeks | 7 | 0 (0%) |
| Total | 121 | 29 (24%) |
F2 progeny from an initial MALS-1 KO chimera and Black Swiss intercross were subjected to an identical sound stimulus, and the percentage of animals seizing was scored.