Table 1.

Effects of ionophoretically applied proteasome inhibitors on sensory responses of single dorsal horn neurons

Drug	Condition	% of stimulus-evoked response remaining
Drug	Condition	Brush	Mustard oil	Cold
Lactacystin		87.5 ± 5.9	58.6 ± 7.1^*
	Naive	(n = 8)	(n = 7)
		(10–60 nA)	(10–60 nA)
		79.2 ± 1.6	50.1 ± 6.2^*
	Sham	(n = 3)	(n = 4)
		(50–60 nA)	(10–40 nA)
		60.8 ± 4.2^*	34.1 ± 5.1	58.7 ± 4.7^*
	Neuropathic	(n = 4)	(n = 6)	(n = 3)
		(20–60 nA)	(20–40 nA)	(10–30 nA)
MG-132		76.4 ± 2.5	57.1 ± 8.8^*
	Naive	(n = 4)	(n = 4)
		(10–40 nA)	(20–40 nA)
		66.4 ± 5.4^*	31.6 ± 2.1^*	48.3 ± 7.4^*
	Neuropathic	(n = 4)	(n = 7)	(n = 3)
		(30–60 nA)	(10–30 nA)	(10–30 nA)

Data are expressed as mean ± SEM (n values in parentheses). Using mean firing rates over 15 sec bins, the statistical significance of differences between maximally inhibited firing rates in the presence of drug and firing rates immediately before ionophoresis were calculated by Kruskal–Wallis one-way ANOVA, followed by apost hoc Dunn's test (
↵* p < 0.05). The ranges of ionophoretic currents required to reach a maximal depression of firing rate are indicated. Further increases in currents beyond these values caused greater inhibition.